Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEK, SKAP2, and C1QB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity versus PLEK in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLEK →	+0.365	+0.033	<.001	.001	3	7
GBM	SKAP2 →	+0.704	+0.049	<.001	<.001	3	6
OV	C1QB →	+0.638	+0.047	<.001	<.001	3	6
OV	C1QC →	+0.745	+0.043	<.001	.002	3	6
CCRCC	CTHRC1 →	+0.919	+0.039	.001	<.001	3	6
GBM	DOCK11 →	+0.362	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042771 vs PLEK — LSCC

Explore this scatter interactively →