Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC17A7, BLCAP, and PPP1R14A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity versus SLC17A7 in GBM (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC17A7 →	-1.363	-0.262	<.001	<.001	3	4
GBM	BLCAP →	-0.388	-0.231	<.001	.007	3	4
GBM	PPP1R14A →	-0.877	-0.196	.003	.002	3	4
GBM	PPP1R12B →	-0.443	-0.258	<.001	<.001	2	5
LUAD	NBPF3 →	-0.324	-0.144	.003	<.001	3	4
GBM	FAM13C →	-0.858	-0.282	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042771 vs SLC17A7 — GBM

Explore this scatter interactively →