Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, MDM2, and EDA2R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-2.173	-0.961	<.001	.001	3	7
SKIN	MDM2 →	-1.480	-1.259	<.001	<.001	3	7
SKIN	EDA2R →	-2.273	-1.585	<.001	<.001	3	5
SKIN	ZMAT3 →	-1.121	-1.111	<.001	<.001	3	5
SKIN	RRM2B →	-1.384	-1.553	<.001	<.001	3	5
STOMACH	DDB2 →	-1.031	-0.735	<.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity — SKIN

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