Regulation of sulfur metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of sulfur metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2K_S445, CD44_S697, and TOPORS_S98, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sulfur metabolic process activity versus EEF2K_S445 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EEF2K_S445 →	-0.503	-0.042	.002	.003	3	6
CCRCC	CD44_S697 →	-0.486	-0.054	.002	<.001	3	5
GBM	TOPORS_S98 →	-0.361	-0.066	<.001	<.001	3	5
CCRCC	PLIN2 →	+0.785	+0.054	.001	.001	2	6
CCRCC	SAMHD1_T592 →	-0.766	-0.061	<.001	<.001	3	4
CCRCC	SCAF4_S656 →	-0.372	-0.073	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042762 vs EEF2K_S445 — GBM

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