Regulation of sulfur metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of sulfur metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00894, APC, and TH2LCRR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sulfur metabolic process activity versus LINC00894 in UCEC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00894 →	+0.532	+0.093	<.001	.007	3	5
CCRCC	APC →	+0.251	+0.124	<.001	.006	3	5
CCRCC	TH2LCRR →	+0.260	+0.100	.009	.009	3	5
HNSC	MAPK10 →	+0.722	+0.142	.001	.007	3	5
BRCA	CTSK →	-0.826	-0.141	.001	.002	3	4
UCEC	RPL36AP43 →	+0.615	+0.132	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042762 vs LINC00894 — UCEC

Explore this scatter interactively →