Regulation of sulfur metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of sulfur metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNNB1, CCKBR, and CDKN2D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNNB1 grouped by Regulation of sulfur metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTNNB1 →	-1.750	-0.418	<.001	.004	3	8
PANCREAS	CCKBR →	-0.201	-0.333	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CDKN2D →	-0.202	-0.251	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ATG4D →	-0.258	-0.217	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	ACP6 →	+0.333	+0.256	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	SSX5 →	-0.115	-0.238	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNNB1 by Regulation of sulfur metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →