Regulation of sulfur metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of sulfur metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL35A, MRPL15, and STS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL35A grouped by Regulation of sulfur metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPL35A →	-0.423	-0.742	.004	.003	3	4
PANCREAS	MRPL15 →	+0.636	+1.167	.004	<.001	3	4
OVARY	STS →	-1.436	-1.210	.001	<.001	3	4
BREAST	LYST →	-1.072	-0.719	<.001	.003	3	3
LUNG_SCLC	HAS3 →	-1.158	-1.057	.003	.004	2	4
LUNG_SCLC	QTRT2 →	-0.711	-1.221	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL35A by Regulation of sulfur metabolic process activity — CNS

Explore this box plot interactively →