Regulation of sulfur metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of sulfur metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL21A, ERO1A, and ICAM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sulfur metabolic process activity versus METTL21A in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	METTL21A →	+0.757	+0.205	.002	.002	3	5
KIDNEY	ERO1A →	-1.385	-0.201	<.001	.003	3	4
CNS	ICAM1 →	-2.193	-0.179	.008	.005	2	5
BONE	PLEKHN1 →	-1.130	-0.421	<.001	<.001	3	4
KIDNEY	MRPL53 →	+0.641	+0.216	.006	<.001	3	4
LUNG_SCLC	LY96 →	-1.556	-0.158	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042762 vs METTL21A — LIVER

Explore this scatter interactively →