Very long-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Very long-chain fatty acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC27A2, KIFBP, and NAA35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very long-chain fatty acid catabolic process activity versus SLC27A2 in BRCA (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC27A2 →	+1.141	+0.070	<.001	<.001	3	6
UCEC	KIFBP →	+0.135	+0.065	.004	<.001	3	6
OV	NAA35 →	+0.201	+0.058	.001	<.001	3	5
PDAC	TXNDC5 →	-0.385	-0.054	<.001	.002	3	5
LSCC	SPRYD4 →	+0.488	+0.087	<.001	<.001	3	5
LSCC	SELENOM →	-0.578	-0.092	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042760 vs SLC27A2 — BRCA

Explore this scatter interactively →