Very long-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Very long-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM1P42, PLA2G2A, and FLVCR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very long-chain fatty acid catabolic process activity versus NPM1P42 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NPM1P42 →	+0.048	+0.181	.007	.003	3	4
GBM	PLA2G2A →	-1.869	-0.137	<.001	.001	3	4
LSCC	FLVCR2 →	+0.475	+0.149	.009	.003	3	4
GBM	C19orf53 →	-0.176	-0.104	.003	<.001	3	4
CCRCC	RN7SL334P →	+0.962	+0.170	.004	.002	3	4
HNSC	PRAM1 →	-0.578	-0.174	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042760 vs NPM1P42 — COAD

Explore this scatter interactively →