Very long-chain fatty acid catabolic process

Across TCGA cell cohorts, RNA activity of the Very long-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLK, NCBP2AS2, and HTR3E, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very long-chain fatty acid catabolic process activity versus POLK in LARGE_INTESTINE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLK →	-0.773	-1.429	.002	<.001	3	3
LARGE_INTESTINE	NCBP2AS2 →	-0.861	-1.457	.005	.001	3	3
OESOPHAGUS	HTR3E →	-0.056	-1.519	.009	<.001	3	2
OESOPHAGUS	HOXA11 →	+2.447	+1.546	<.001	<.001	3	2
BLOOD_Leukemia	APLP2 →	+3.099	+1.280	<.001	.001	3	2
BLOOD_Leukemia	SMTN →	-1.552	-1.517	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042760 vs POLK — LARGE_INTESTINE

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