Long-chain fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTM4, SLC9A3R1_S269, and GSTM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid biosynthetic process activity versus GSTM4 in LSCC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GSTM4 →	+1.093	+0.043	.001	.005	3	5
HNSC	SLC9A3R1_S269 →	+0.486	+0.056	<.001	.001	3	5
LSCC	GSTM2 →	+1.101	+0.044	<.001	.004	3	4
CCRCC	NSMCE3 →	-0.188	-0.038	.003	.007	3	4
PDAC	PDS5A →	-0.129	-0.024	<.001	.009	3	4
HNSC	ZNF592 →	-0.238	-0.068	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042759 vs GSTM4 — LSCC

Explore this scatter interactively →