Long-chain fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTM1, GSTM4, and GSTM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid biosynthetic process activity versus GSTM1 in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSTM1 →	+2.547	+0.275	<.001	<.001	3	8
LSCC	GSTM4 →	+0.585	+0.132	.006	.001	3	6
LSCC	GSTM2 →	+0.918	+0.150	<.001	.002	3	5
LSCC	ALDH3A1 →	+2.547	+0.164	<.001	.001	3	4
OV	SLAMF1 →	+0.597	+0.207	.001	.001	3	4
LUAD	NAP1L2 →	+0.823	+0.180	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042759 vs GSTM1 — BRCA

Explore this scatter interactively →