Long-chain fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCZ, POMT2, and SULT1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCZ grouped by Long-chain fatty acid biosynthetic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRKCZ →	-0.178	-0.155	.001	.003	3	5
LUNG_NSCLC_LUAD	POMT2 →	-0.169	-0.175	<.001	<.001	3	4
URINARY_TRACT	SULT1B1 →	+0.249	+0.226	<.001	<.001	3	4
STOMACH	TOM1L1 →	-0.241	-0.240	<.001	<.001	3	4
LUNG_SCLC	HRH2 →	-0.117	-0.192	.002	.006	3	4
LUNG_SCLC	RACGAP1 →	-0.336	-0.264	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCZ by Long-chain fatty acid biosynthetic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →