Long-chain fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT7, ZEB1, and PRRG2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid biosynthetic process activity versus ACOT7 in OVARY (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACOT7 →	+1.554	+0.381	<.001	.003	3	7
OVARY	ZEB1 →	+2.346	+0.287	<.001	<.001	3	6
OVARY	PRRG2 →	-1.909	-0.237	<.001	.003	3	5
OVARY	ZNF438 →	+0.767	+0.288	<.001	<.001	3	5
OVARY	LIX1L →	+1.321	+0.359	.001	<.001	3	5
LUNG_NSCLC_LUAD	GSTP1 →	+4.147	+1.008	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042759 vs ACOT7 — OVARY

Explore this scatter interactively →