Long-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLYATL2, KCTD5, and TALDO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid catabolic process activity versus GLYATL2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLYATL2 →	+1.526	+0.158	<.001	<.001	3	4
BRCA	KCTD5 →	+0.239	+0.092	.004	<.001	3	4
LSCC	TALDO1 →	+0.399	+0.092	.001	<.001	3	4
CCRCC	AIFM1 →	+0.281	+0.075	.002	<.001	3	4
UCEC	NBL1 →	-0.491	-0.097	.002	<.001	3	4
UCEC	AACS →	+0.446	+0.123	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042758 vs GLYATL2 — UCEC

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