Long-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2U1-AS1, KNOP1, and NUP107, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid catabolic process activity versus CYP2U1-AS1 in OV (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP2U1-AS1 →	+0.116	+0.931	.006	.006	2	5
UCEC	KNOP1 →	-0.401	-0.593	.005	.009	3	3
CCRCC	NUP107 →	-0.204	-0.171	.006	<.001	3	3
CCRCC	DCP1B →	-0.277	-0.169	<.001	.006	3	3
CCRCC	RSL1D1 →	-0.206	-0.165	.002	<.001	3	3
UCEC	KLB →	+0.560	+0.654	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042758 vs CYP2U1-AS1 — OV

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