Drinking behavior

Across TCGA patient cohorts, RNA activity of the Drinking behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN1, EVL_S246, and HID1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Drinking behavior activity versus SEPTIN1 in LSCC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN1 →	-0.529	-0.517	<.001	<.001	3	7
LSCC	EVL_S246 →	-0.527	-0.636	.001	<.001	3	6
COAD	HID1 →	-0.399	-0.057	.007	<.001	3	6
LSCC	IL16 →	-0.444	-0.634	<.001	<.001	3	6
BRCA	PAPLN →	-0.546	-0.083	<.001	<.001	3	6
BRCA	MCM6_S762 →	+1.010	+0.044	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042756 vs SEPTIN1 — LSCC

Explore this scatter interactively →