Drinking behavior

Across TCGA cell cohorts, RNA activity of the Drinking behavior pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOB3C, ZFAND1, and IQSEC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOB3C grouped by Drinking behavior-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MOB3C →	-0.724	-0.790	.001	.009	3	5
CNS	ZFAND1 →	+0.651	+0.869	.002	.002	3	4
CNS	IQSEC2 →	-1.320	-0.902	.001	.008	3	4
BLOOD_Lymphoma	UQCRQ →	-0.780	-1.833	.001	<.001	3	4
BLOOD_Lymphoma	CNTLN →	-2.602	-1.664	.003	<.001	3	4
BLOOD_Lymphoma	HMOX1 →	-3.169	-1.649	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOB3C by Drinking behavior activity — CNS

Explore this box plot interactively →