Eating behavior

Across TCGA patient cohorts, RNA activity of the Eating behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIAP82, MTMR3, and EDEM3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eating behavior activity versus PPIAP82 in PDAC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPIAP82 →	-0.074	-0.149	.002	.002	3	3
BRCA	MTMR3 →	-0.270	-0.175	.002	.007	3	2
BRCA	EDEM3 →	-0.584	-0.149	<.001	.006	3	2
BRCA	TGFB3 →	-0.778	-0.153	<.001	.005	3	2
BRCA	TRERF1 →	-0.562	-0.182	.002	<.001	3	2
BRCA	TSTD2 →	-0.372	-0.149	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042755 vs PPIAP82 — PDAC

Explore this scatter interactively →