Regulation of circadian rhythm

Across TCGA patient cohorts, RNA activity of the Regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, MMS22L, and MTFR2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of circadian rhythm activity versus NCAPH in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCAPH →	+0.756	+0.143	<.001	<.001	3	7
UCEC	MMS22L →	+0.708	+0.304	.001	.002	3	7
LSCC	MTFR2 →	+0.992	+0.323	<.001	<.001	3	7
LSCC	RAD54L →	+1.167	+0.304	<.001	<.001	3	7
UCEC	HJURP →	+1.274	+0.279	.001	.001	3	7
BRCA	CDCA8 →	+0.850	+0.142	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042752 vs NCAPH — BRCA

Explore this scatter interactively →