Circadian sleep/wake cycle

Across TCGA patient cohorts, RNA activity of the Circadian sleep/wake cycle pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBA7, WAS, and SASH3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian sleep/wake cycle activity versus UBA7 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBA7 →	-0.343	-0.064	.002	<.001	3	5
BRCA	WAS →	-0.445	-0.091	<.001	<.001	3	5
CCRCC	SASH3 →	-0.394	-0.102	<.001	<.001	3	5
BRCA	STING1 →	-0.288	-0.060	.002	<.001	3	5
CCRCC	VAV1 →	-0.386	-0.107	<.001	<.001	3	5
BRCA	ZAP70 →	-0.601	-0.083	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042745 vs UBA7 — GBM

Explore this scatter interactively →