Circadian sleep/wake cycle

Across TCGA patient cohorts, RNA activity of the Circadian sleep/wake cycle pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR63, CAVIN1, and KIF14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian sleep/wake cycle activity versus GPR63 in UCEC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPR63 →	+0.985	+0.770	<.001	<.001	3	5
PDAC	CAVIN1 →	-0.456	-0.542	<.001	.001	3	5
HNSC	KIF14 →	+0.757	+0.813	<.001	<.001	3	4
HNSC	BEX2 →	+1.015	+0.588	<.001	<.001	3	4
HNSC	TAF5 →	+0.343	+0.420	.005	.008	3	4
LSCC	TMEM231 →	+0.405	+0.607	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042745 vs GPR63 — UCEC

Explore this scatter interactively →