Circadian sleep/wake cycle

Across TCGA cell cohorts, RNA activity of the Circadian sleep/wake cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM5B, RDH10, and TP53INP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM5B grouped by Circadian sleep/wake cycle-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KDM5B →	-0.880	-0.401	.002	.006	3	2
UPPER_AERODIGESTIVE_TRACT	RDH10 →	-2.665	-0.572	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	TP53INP1 →	-2.134	-0.522	.002	.004	3	2
UPPER_AERODIGESTIVE_TRACT	DDO →	-0.460	-0.532	.004	.004	3	2
UPPER_AERODIGESTIVE_TRACT	PDK2 →	-1.209	-0.402	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	OCEL1 →	-1.011	-0.363	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM5B by Circadian sleep/wake cycle activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →