Hydrogen peroxide catabolic process

Across TCGA patient cohorts, RNA activity of the Hydrogen peroxide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC1A, MIR223HG, and S100A8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide catabolic process activity versus CLEC1A in CCRCC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLEC1A →	+0.551	+0.220	.007	.006	3	7
LSCC	MIR223HG →	+0.963	+0.133	<.001	.001	3	7
GBM	S100A8 →	+1.369	+0.239	<.001	<.001	3	7
GBM	PADI4 →	+0.416	+0.195	<.001	<.001	3	7
CCRCC	BCL6B →	+0.692	+0.226	.004	.006	3	6
LSCC	CCL2 →	+0.924	+0.139	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042744 vs CLEC1A — CCRCC

Explore this scatter interactively →