Hydrogen peroxide metabolic process

Across TCGA patient cohorts, RNA activity of the Hydrogen peroxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, CLEC7A, and BIN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide metabolic process activity versus LILRB2 in GBM (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB2 →	+1.091	+0.238	<.001	<.001	3	9
GBM	CLEC7A →	+0.970	+0.191	<.001	<.001	3	9
GBM	BIN2 →	+0.797	+0.220	<.001	<.001	3	9
GBM	HK3 →	+1.481	+0.224	<.001	<.001	3	8
GBM	LILRB3 →	+1.201	+0.256	<.001	<.001	3	8
GBM	CSF2RB →	+1.058	+0.241	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042743 vs LILRB2 — GBM

Explore this scatter interactively →