Fibrinolysis

Across TCGA cell cohorts, RNA activity of the Fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG8, C14orf93, and WDR59, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COG8 grouped by Fibrinolysis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	COG8 →	+0.686	+1.337	.002	<.001	3	4
LIVER	C14orf93 →	+0.630	+1.576	<.001	.002	3	4
KIDNEY	WDR59 →	+1.278	+1.545	.002	<.001	3	4
KIDNEY	VPS4A →	+0.681	+1.388	.001	.002	3	4
KIDNEY	AP1G1 →	+0.968	+1.478	.006	.001	3	4
KIDNEY	LBX2 →	+1.627	+1.703	.003	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COG8 by Fibrinolysis activity — OVARY

Explore this box plot interactively →