Fibrinolysis

Across TCGA cell cohorts, RNA activity of the Fibrinolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF5, HDAC3, and IL27RA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF5 grouped by Fibrinolysis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGEF5 →	-0.097	-0.696	.008	.006	3	2
LUNG_NSCLC_LUAD	HDAC3 →	-0.198	-0.849	.006	.003	2	3
PANCREAS	IL27RA →	+0.308	+1.416	<.001	<.001	3	2
PANCREAS	CCND2 →	-0.266	-1.167	.001	.002	3	2
PANCREAS	YWHAH →	-0.308	-1.645	<.001	<.001	3	2
PANCREAS	MKRN1 →	+0.196	+1.416	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF5 by Fibrinolysis activity — SKIN

Explore this box plot interactively →