Fibrinolysis

Across TCGA cell cohorts, RNA activity of the Fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL16A1, PRPF4, and MRPL53, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibrinolysis activity versus COL16A1 in OESOPHAGUS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COL16A1 →	+2.405	+0.650	<.001	<.001	3	3
LIVER	PRPF4 →	-0.605	-0.462	.004	.008	3	3
KIDNEY	MRPL53 →	+0.760	+0.425	.008	.009	3	3
BLOOD_Myeloma	IGLON5 →	+0.384	+0.520	.008	.005	3	3
URINARY_TRACT	RAN →	-0.668	-0.485	.004	.001	3	3
URINARY_TRACT	UBAP2 →	-0.683	-0.485	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042730 vs COL16A1 — OESOPHAGUS

Explore this scatter interactively →