Flavin-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Flavin-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SEPTIN7, and REXO4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavin-containing compound metabolic process activity versus SMC2 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.569	+0.089	<.001	<.001	3	6
LSCC	SEPTIN7 →	-0.210	-0.063	<.001	<.001	3	6
LSCC	REXO4 →	+0.463	+0.050	<.001	.001	3	6
GBM	DNAJA1 →	+0.152	+0.051	<.001	.001	3	6
OV	POLE3 →	+0.433	+0.070	.002	<.001	3	6
OV	HSPH1_T815 →	+0.956	+0.088	.004	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042726 vs SMC2 — GBM

Explore this scatter interactively →