Flavin-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Flavin-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1E, ADAM20, and PLAA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavin-containing compound metabolic process activity versus POLR1E in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	POLR1E →	+1.298	+0.167	.001	.003	3	5
BREAST	ADAM20 →	-0.062	-0.172	.008	<.001	3	4
BLOOD_Lymphoma	PLAA →	+1.228	+0.156	.006	.002	3	4
LARGE_INTESTINE	RNF149 →	-0.582	-0.115	.001	.001	3	4
STOMACH	TUBA1B →	+0.891	+0.166	.005	<.001	3	4
STOMACH	MDFI →	-3.675	-0.187	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042726 vs POLR1E — BLOOD_Lymphoma

Explore this scatter interactively →