Thiamine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Thiamine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTCD2, NEDD4, and NCK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTCD2 grouped by Thiamine-containing compound metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTCD2 →	-0.616	-0.763	.005	.002	3	4
OVARY	NEDD4 →	-1.175	-0.827	<.001	<.001	3	4
LARGE_INTESTINE	NCK2 →	+1.001	+0.408	.004	.007	3	4
LUNG_SCLC	PRUNE2 →	+2.925	+0.969	.001	<.001	3	4
LUNG_SCLC	FEZ2 →	-2.278	-1.381	<.001	.002	3	3
OVARY	NOTCH3 →	+2.131	+0.931	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTCD2 by Thiamine-containing compound metabolic process activity — OVARY

Explore this box plot interactively →