Thiamine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Thiamine-containing compound metabolic process pathway is significantly associated with the total protein of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FASN, Annexin_VII, and JAK2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thiamine-containing compound metabolic process activity versus FASN in LUNG_SCLC (Pearson r = -0.95).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FASN →	-0.929	-0.410	.020	.017	1	2
LUNG_SCLC	Annexin_VII →	+0.465	+0.410	.006	.017	1	2
LUNG_SCLC	JAK2 →	-0.304	-0.410	.024	.017	1	1
LUNG_SCLC	JNK2 →	+0.626	+0.410	.006	.017	1	1
LUNG_SCLC	p70-S6K →	-0.661	-0.410	.048	.017	1	1
LUNG_SCLC	14-3-3_epsilon →	-0.225	-0.410	.015	.017	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042723 vs FASN — LUNG_SCLC

Explore this scatter interactively →