Sperm ejaculation

Across TCGA patient cohorts, RNA activity of the Sperm ejaculation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5R2, PTGES3P3, and CAP1P1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm ejaculation activity versus CYB5R2 in UCEC (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYB5R2 →	-1.155	-0.253	<.001	.003	3	2
UCEC	PTGES3P3 →	+0.768	+0.201	.008	.005	3	2
LSCC	CAP1P1 →	+0.640	+0.207	.004	.002	3	2
UCEC	ACO1 →	+0.613	+0.191	.009	.009	3	1
UCEC	LAMP5 →	-2.809	-0.228	.001	.001	3	1
UCEC	LANCL2 →	-0.720	-0.259	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042713 vs CYB5R2 — UCEC

Explore this scatter interactively →