Ovulation cycle

Across TCGA cell cohorts, RNA activity of the Ovulation cycle pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF38A, TAF5, and PPP1R2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF38A grouped by Ovulation cycle-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRPF38A →	+0.626	+0.930	<.001	<.001	3	4
KIDNEY	TAF5 →	+0.574	+0.860	.003	.008	3	4
KIDNEY	PPP1R2 →	+0.587	+1.077	.005	.002	3	4
KIDNEY	HUWE1 →	+0.557	+0.851	.004	.001	3	4
LUNG_NSCLC_LUAD	SNIP1 →	+0.435	+0.416	.007	.009	3	4
KIDNEY	MYBL2 →	+1.098	+0.923	.008	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF38A by Ovulation cycle activity — KIDNEY

Explore this box plot interactively →