Ovulation cycle

Across TCGA cell cohorts, RNA activity of the Ovulation cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA5, PTPRB, and PCOLCE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMA5 grouped by Ovulation cycle-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LAMA5 →	-0.232	-0.377	.001	.001	3	4
BONE	PTPRB →	-0.415	-0.202	.007	.008	3	4
SKIN	PCOLCE →	+0.317	+0.284	.009	.009	2	4
LUNG_SCLC	EXOG →	+0.225	+0.233	.005	.003	3	3
LUNG_SCLC	GP1BA →	-0.258	-0.512	<.001	.002	3	3
LUNG_SCLC	UVRAG →	-0.263	-0.303	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMA5 by Ovulation cycle activity — BLOOD_Leukemia

Explore this box plot interactively →