Muscle cell fate commitment

Across TCGA patient cohorts, RNA activity of the Muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX2, MEF2C, and TBX3, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell fate commitment activity versus TBX2 in BLCA (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TBX2 →	+2.057	+0.100	<.001	<.001	3	23
UCS	MEF2C →	+1.482	+0.117	<.001	<.001	3	21
UCS	TBX3 →	+2.603	+0.149	<.001	<.001	2	21
BLCA	TBX2-AS1 →	+2.193	+0.101	<.001	<.001	3	20
THYM	SPRY1 →	+1.333	+0.068	<.001	<.001	3	19
UVM	EDNRB →	+1.729	+0.077	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042693 vs TBX2 — BLCA

Explore this scatter interactively →