Muscle cell fate commitment

Across TCGA patient cohorts, RNA activity of the Muscle cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID1, SORBS3, and SSC5D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell fate commitment activity versus NID1 in CCRCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NID1 →	+0.431	+0.106	<.001	<.001	3	7
UCEC	SORBS3 →	+0.422	+0.091	<.001	.001	3	6
PDAC	SSC5D →	+0.736	+0.095	<.001	<.001	3	6
BRCA	TNS2 →	+0.360	+0.055	<.001	<.001	3	6
LUAD	UACA →	+0.351	+0.076	<.001	<.001	3	6
UCEC	SPARCL1_S59 →	+0.951	+0.090	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042693 vs NID1 — CCRCC

Explore this scatter interactively →