Muscle cell fate commitment

Across TCGA patient cohorts, RNA activity of the Muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP12, TBX2, and RHOJ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell fate commitment activity versus CASP12 in CCRCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CASP12 →	+0.688	+0.722	<.001	<.001	3	7
CCRCC	TBX2 →	+0.991	+0.658	<.001	<.001	3	6
UCEC	RHOJ →	+0.873	+0.256	.001	.002	3	6
CCRCC	EBF1 →	+0.772	+0.618	<.001	<.001	3	6
UCEC	LAMA2 →	+1.028	+0.339	<.001	.001	3	6
UCEC	CEROX1 →	+0.437	+0.290	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042693 vs CASP12 — CCRCC

Explore this scatter interactively →