Muscle cell fate commitment

Across TCGA cell cohorts, RNA activity of the Muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPRD1A, TATDN3, and CLCF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPRD1A grouped by Muscle cell fate commitment-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RPRD1A →	+0.950	+1.139	<.001	<.001	3	6
LARGE_INTESTINE	TATDN3 →	+0.741	+0.902	.001	.005	3	6
URINARY_TRACT	CLCF1 →	-1.683	-1.442	.001	.001	3	5
STOMACH	PERM1 →	-0.727	-0.949	.004	.004	3	5
STOMACH	SAMD9 →	-2.352	-1.300	<.001	<.001	3	5
STOMACH	GCFC2 →	+0.769	+1.040	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPRD1A by Muscle cell fate commitment activity — LIVER

Explore this box plot interactively →