Muscle cell fate commitment

Across TCGA cell cohorts, RNA activity of the Muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1, PKP3, and PLEKHA7, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell fate commitment activity versus ACVR1 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ACVR1 →	+1.348	+1.278	<.001	.001	3	12
OVARY	PKP3 →	-2.318	-1.005	<.001	<.001	3	8
OVARY	PLEKHA7 →	-1.844	-1.388	<.001	<.001	3	7
BLOOD_Leukemia	MEF2C →	+2.931	+0.825	<.001	<.001	3	7
PANCREAS	ATE1 →	+0.589	+1.046	.009	.001	3	6
OVARY	CDS1 →	-1.646	-1.107	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042693 vs ACVR1 — LIVER

Explore this scatter interactively →