Retinal cone cell differentiation

Across TCGA patient cohorts, RNA activity of the Retinal cone cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYM, ANKS4B, and SEL1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal cone cell differentiation activity versus CRYM in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRYM →	+1.085	+0.571	<.001	<.001	3	4
COAD	ANKS4B →	+0.479	+0.150	<.001	<.001	3	4
CCRCC	SEL1L →	-0.158	-0.119	.009	.005	3	4
PDAC	SLC22A18 →	+0.350	+0.312	.005	.007	3	3
HNSC	GLIPR2 →	+0.382	+0.560	.005	.005	3	3
BRCA	CTBP2P6 →	+0.180	+0.368	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042670 vs CRYM — GBM

Explore this scatter interactively →