Retinal cone cell differentiation

Across TCGA cell cohorts, RNA activity of the Retinal cone cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USH1C, PGP, and CD93, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USH1C grouped by Retinal cone cell differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	USH1C →	-0.339	-1.683	.003	.001	3	5
BREAST	PGP →	-0.203	-0.751	.001	.001	3	4
SKIN	CD93 →	-0.165	-1.025	.005	.003	3	4
SKIN	ACADVL →	+0.124	+0.583	.003	.007	3	4
LUNG_NSCLC_LUSC	ADCY10 →	-0.149	-1.108	<.001	.002	3	3
LUNG_NSCLC_LUSC	RNF180 →	+0.165	+1.305	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USH1C by Retinal cone cell differentiation activity — OESOPHAGUS

Explore this box plot interactively →