Regulation of hair cycle

Across TCGA patient cohorts, RNA activity of the Regulation of hair cycle pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF782, TRPM7, and SAMHD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hair cycle activity versus ZNF782 in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF782 →	+0.561	+0.478	<.001	<.001	3	5
GBM	TRPM7 →	+0.209	+0.461	.004	.007	3	4
HNSC	SAMHD1 →	-0.669	-0.564	.003	.001	3	4
HNSC	GPR65 →	-0.766	-0.499	<.001	.003	3	4
HNSC	LAIR1 →	-0.756	-0.441	<.001	.009	3	4
HNSC	CSF1R →	-0.924	-0.488	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042634 vs ZNF782 — LSCC

Explore this scatter interactively →