Regulation of hair cycle

Across TCGA cell cohorts, RNA activity of the Regulation of hair cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREBZF, NUMA1, and HAGH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREBZF grouped by Regulation of hair cycle-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CREBZF →	-0.372	-0.429	.005	.005	3	5
LUNG_NSCLC_LUAD	NUMA1 →	-0.217	-0.517	<.001	<.001	3	5
SOFT_TISSUE	HAGH →	-0.338	-0.338	.003	<.001	3	4
SOFT_TISSUE	EYA2 →	-0.185	-0.312	.004	.001	3	4
CNS	GNG4 →	+0.164	+0.725	.009	.002	3	4
UPPER_AERODIGESTIVE_TRACT	AFP →	-0.131	-0.227	.009	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREBZF by Regulation of hair cycle activity — SOFT_TISSUE

Explore this box plot interactively →