Response to starvation

Across TCGA patient cohorts, RNA activity of the Response to starvation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, HTRA1, and SERBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to starvation activity versus TIMP2 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.573	+0.024	<.001	<.001	3	7
BRCA	HTRA1 →	+0.848	+0.022	<.001	.001	3	7
OV	SERBP1 →	-0.286	-0.040	.003	.001	3	6
GBM	ACSL1 →	+0.498	+0.026	<.001	<.001	3	6
COAD	THBS2 →	+1.341	+0.019	<.001	<.001	3	6
BRCA	AEBP1 →	+0.732	+0.026	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042594 vs TIMP2 — BRCA

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