Response to starvation

Across TCGA cell cohorts, RNA activity of the Response to starvation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS4, MAX, and FBXL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAMTS4 grouped by Response to starvation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAMTS4 →	-0.213	-0.130	.002	.009	3	5
LUNG_NSCLC_LUSC	MAX →	-0.430	-0.208	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	FBXL4 →	-0.198	-0.183	.007	.002	3	5
STOMACH	OGDH →	-0.531	-0.168	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NTSR1 →	-0.204	-0.183	<.001	<.001	3	4
SKIN	LGALS8 →	-0.098	-0.109	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAMTS4 by Response to starvation activity — BLOOD_Leukemia

Explore this box plot interactively →