Response to starvation

Across TCGA cell cohorts, RNA activity of the Response to starvation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF138, SATL1, and OXTR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF138 grouped by Response to starvation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNF138 →	+1.150	+0.204	.005	<.001	3	5
LUNG_NSCLC_LUAD	SATL1 →	+0.156	+0.135	.009	.001	3	5
CNS	OXTR →	-1.605	-0.158	.004	.003	3	4
STOMACH	HSD17B7 →	+1.061	+0.098	<.001	.002	3	4
LUNG_NSCLC_LUSC	GBP1 →	-2.351	-0.215	<.001	<.001	3	4
BONE	LMCD1 →	-3.972	-0.147	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF138 by Response to starvation activity — BONE

Explore this box plot interactively →