Response to starvation

Across TCGA cell cohorts, RNA activity of the Response to starvation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPCAL1, LYRM7, and PDCL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to starvation activity versus HPCAL1 in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HPCAL1 →	+1.246	+0.130	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	LYRM7 →	+1.314	+0.141	.001	.004	3	5
PANCREAS	PDCL3 →	+1.030	+0.182	<.001	<.001	3	5
PANCREAS	RPP40 →	+1.271	+0.133	.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	NDUFA10 →	+0.821	+0.140	.004	.002	3	5
UPPER_AERODIGESTIVE_TRACT	RPL26L1 →	+0.957	+0.145	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042594 vs HPCAL1 — BREAST

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