Response to starvation

Across TCGA cell cohorts, RNA activity of the Response to starvation pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPG1, SBDS, and RPS18, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to starvation activity versus COPG1 in PANCREAS (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COPG1 →	+1.474	+0.188	<.001	<.001	3	11
OVARY	SBDS →	+1.342	+0.154	.003	.001	3	10
PANCREAS	RPS18 →	+1.081	+0.168	<.001	<.001	3	10
PANCREAS	GARS1 →	+1.180	+0.168	<.001	.001	3	9
PANCREAS	RARS1 →	+0.799	+0.128	<.001	.008	3	9
PANCREAS	FARSB →	+1.461	+0.181	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042594 vs COPG1 — PANCREAS

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